Comparison of species sensitivity; are the effects of thyroid hormone disrupting compounds comparable between tadpoles of the common frog (Rana temporaria) and the model species Xenopus?

go back
Project duration February 01, 2018 to December 31, 2021
Funding Body --


Eggs of the common frog are exposed to well-known thyroid disrupting compounds throughout tadpole development, and the chemicals have already been tested in Xenopus (LAGDA/AMA). The exposure duration is approx 6 weeks and the eggs are collected in nature. The exposure setup is a flow through system and the actual chemical concentrations are determined by LC-MSMS. The endpoints are thyroid gland and eye histology, biometric measurements (e.g. hind limb length), developmental stage and thyroid hormone levels, and the data are compared with already published data on Xenopus.

PERIAMAR members


Additional information

Chemical Pharmaceuticals
Taxa Amphibia
Study Framework Laboratory experiment


New potential biomarkers for thyroid hormone disruption Comparison of species sensitivity Thyroid hormone levels Thyroid gland histology